January 26, 2011
Nature Biotechnology recently asked leading computational biology researchers to nominate papers of particular interest published in 2010 that influenced the direction of their research. Work from Bob Murphy’s group was chosen as one of four papers highlighted in the resulting article. The featured work, originally described in papers in the Proceedings of the National Academy of Sciences, U.S.A. and Bioinformatics, was the first to provide an automated means of estimating from microscope images how much of a protein (or other marker) is present in different subcellular organelles. The research involved a collaboration with scientists Ghislain Bonamy, Daniel R. Rines, and Sumit K. Chanda from the Genomics Institute of the Novartis Research Foundation in San Diego, and was carried out by graduate students Tao Peng and Luis Pedro Coelho and postdoctoral fellow Estelle Glory-Afshar.