Joel McManusAssistant Professor Carnegie Mellon UniversityDepartment of Biological Sciences and Computational Biology Department
The McManus lab has two research projects at CMU. The first project is aimed at understanding how genomic differences affect gene expression. Gene expression involves transcription of DNA into mRNA, alternative splicing of mRNA, translation of the mRNA into proteins, and regulation of mRNA and protein levels through degradation pathways. Differences in the networks controlling these processes lead to gene expression variation, which is an important source of phenotypic diversity. Most research in this area has focused on transcription networks and mRNA abundance, because these are the easiest to study. The McManus lab investigates changes in splicing and translation regulatory networks using high throughput sequencing and bioinformatics. The second project uses these same tools to investigate mRNA secondary structure genome wide. mRNA structures play a large role in gene expression, yet very little is known about the structures of most mRNAs.